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Enzyme Engineering
Peptide ligases are powerful biocatalysts capable of joining proteins and peptides, enabling applications in protein engineering, synthetic biology and drug discovery.
We have established a directed evolution platform which employs a split-protein reporter to couple ligase activity to cell growth. This platform is allowing us to explore significantly larger sequence spaces to engineer novel biocatalysts for peptide and protein editing.
Cyclic Peptide Drug Discovery
Cyclic peptides are an emerging therapeutic class offering access to challenging protein targets.
Synthesis of dead-to-tail cyclic peptides are challenging and presents a bottleneck for hit discovery.
We are developing an engineered bacterial system capable of generating and screening millions of recombinantly produced post-translationally modified cyclic peptides to identify antagonists of disease relevant protein interactions.
Our research aims to develop new biological tools and systems for designing, building, and modifying molecules for healthcare and biotechnology. We combine enzyme engineering, directed evolution, and synthetic biology to create versatile platforms that accelerate the discovery of new therapeutics and enable the precise assembly of next-generation bioconjugates.
Research in the Tang Lab
Funding
We are grateful to the following organisations for their ongoing support:
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University of Bath
BBSRC
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